Patienten mit einer frequent gene variant must be maintained for longer after bypass surgery in the ICU. This report Canadian researchers in Critical Care (online edition).
The genetic variant influences the concentration of interleukin 18 (IL-18), the experts have a material impact on inflammatory response after surgery to update. Previous studies had shown that high IL-18 levels are often associated with a complicated postoperative course.
Keith Walley from the University of British Columbia in Vancouver, this now leads back to a point mutation in the IL18 gene. Institution of the so-called TT genotype in the 9545 T / G polymorphism had three times more likely longer than three days in the ICU stay than patients with other variants of TG or GG.
Walley suggested that the TT genotype increases the expression of IL-18 and thus increases the post-operative inflammation. A clinical relevance stems from the fact that 58 percent of the patients were carriers TT genotype, so the more the rule than the exception is. http://ccforum.com/imedia/2945597102206208_article.pdf
© RME / aerzteblatt.de
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