One in 25 people in the Indian subcontinent, the carrier of a gene variant that of a five- cases in late adulthood leads to heart failure. This is an international group of researchers reported in Nature Genetics (2009, doi: 10.1038/ng.309).
The gene contains the information for the cardiac myosin binding protein C (MYBPC3). It is part of the sarcomere, namely the contraction of the muscle apparatus. The mutation leads to loss of 25 letters of the genetic code.
's group from the Madurai Kamaraj Perundurai Dhandapany University, Madurai (in the southern Indian state of Tamil Nadu) estimates that the deletion is approximately 30,000 years old. It is therefore older than the cultural caste system and therefore on all social boundaries in all the tribes and the followers of different religions, India in the eighth on a very segregation represented. The high prevalence of 4 percent, the researchers explain the fact that the cardiomyopathy is manifest only in late adulthood, and therefore no negative selection is suspended.
carriers of the gene have a seven-fold increased risk of a cardiomyopathy. The lifetime risk is indicated by 25 percent. This and the very high prevalence of the gene to make according to the British Heart Foundation, a screening under the British South Asian origin (along with India that includes Pakistan and Sri Lanka) certainly debatable. admit it but still no idea how the could be helped in this way discovered people said A spokesman of the Society of British cardiologist.
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